Alzheimer’氏病（AD）是西方世界中最常见的痴呆（影响大脑的福利彩票3d试机号）形式。但是，尚无可治愈这种破坏性神经退行性福利彩票3d试机号的方法。这种福利彩票3d试机号的特征是称为β淀粉样蛋白（Aβ）在大脑中积累形成称为‘plaques’ and ‘tangles’ (1). This leads to the loss of connections between nerve cells, and eventually to the death of nerve cells and loss of brain tissue. Since 老年痴呆症’s is a progressive disease, this means that gradually, over time, more parts of the brain will be damaged. As this happens, more symptoms develop and become more severe. Some of the symptoms of 老年痴呆症’s是记忆力减退，混乱，无法学习新事物，幻觉和冲动行为（2）。
But what does 老年痴呆症’的福利彩票3d试机号与肠道菌群有关？
Similarly, recent studies have showed marked differences in the gut bacteria composition between mice suffering from 老年痴呆症's and healthy mice (4). Researchers also studied 老年痴呆症’s disease in mice that completely lacked bacteria to further test the relationship between intestinal bacteria and the disease. The results showed that mice without bacteria had a significantly smaller amount of beta amyloid 斑块 in the brain (recall: Beta-amyloid 斑块 are the lumps that form at the nerve fibres in cases of 老年痴呆症's disease).
Furthermore, in order to clarify the link between intestinal bacteria and the occurrence of the disease, the researchers transferred intestinal bacteria from diseased mice to germ-free mice (meaning mice free of bacteria), and discovered that the mice developed more beta-amyloid 斑块 in the brain compared to if they had received bacteria from healthy mice (4). Overall, that’s all a very scientific way to say that a healthier gut appears to lead to both a lower incidence of 老年痴呆症’并在福利彩票3d试机号确实较轻时发生。
These are very promising results and they have the potential for opening new area for the treatment and prevention of 老年痴呆症’s disease and ultimately other neurodegenerative disorders. In fact, researchers will continue to study the role of bacteria in the development of 老年痴呆症's disease, and test entirely new types of preventive and therapeutic strategies based on the modulation of the gut microbiota through diet and new types of probiotics.
1. Park, Laibaik, Ken Uekawa, Lidia Garcia-Bonilla, Kenzo Koizumi, Michelle Murphy, Rose Pitstick, Linda H. Younkin, Steven G. Younkin, Ping Zhou, Geroge A. Carlson, Josef Anrather, and Costantino Iadecola. "Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of 老年痴呆症 AÎ² Peptides." 循环研究 （2017）：n。帕格
2. Society, 老年痴呆症's. "老年痴呆症's Disease." 老年痴呆症's Society. 老年痴呆症's Society, 11 Nov. 2016. Web.
3. O’Toole, P. W. &Jeffery，I. B.肠道菌群和衰老。 科学 350、1214–1215, (2015).
4. Harach，T.，N。Marungruang，N。Duthilleul，V。Cheatham，K。D. Mc Coy，G。Frisoni，J。J. Neher，F。FÃ¥k，M。Jucker，T。Lasser和T. Bolmont。 “在没有肠道菌群的情况下减少APPPS1转基因小鼠的Abeta淀粉样蛋白病理。” 科学报告 7（2017）：41802。